Plain-English translation of NCT07482943 on ClinicalTrials.gov ↗ ·
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether a medication called dapagliflozin can help improve heart function and exercise ability in teenagers and adults who have had Fontan surgery. Fontan surgery is performed for people born with a single functioning heart chamber instead of the normal two. Researchers want to see if this medication might help the heart work better and improve quality of life.
After Fontan surgery, the heart has to work harder than normal, which can lead to heart failure and reduced exercise capacity over time. Researchers are studying whether this medication might help protect the heart and improve how well patients can exercise.
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You would take the medication once daily by mouth for 12 weeks. You'll have three clinic visits where your heart will be checked with blood tests, heart recordings, and exercise tests. At the beginning and end, you'll also complete questionnaires about how you're feeling and your quality of life. The whole study lasts about 3 months.
AI-generated summary from trial data · Aug 6, 2026 · Not medical advice
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