Plain-English translation of NCT07487090 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial tests whether the timing of meals relative to exercise affects weight loss and heart health. You would exercise 4 days per week for 16 weeks, either before breakfast (fasted) or after eating a meal. Researchers want to understand whether your body responds differently to exercise depending on whether you've eaten recently, and how this might affect hunger, eating behaviors, and overall weight loss.
When people exercise, their bodies often compensate by eating more afterward, which can limit weight loss. This study will help determine whether exercising before breakfast might reduce this compensatory eating and lead to better weight loss results compared to exercising after eating.
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You would be randomly assigned to either exercise before breakfast (after fasting 8–12 hours) or within 3 hours after eating a meal. Either way, you would attend supervised aerobic exercise sessions 4 days per week, early in the morning between 5 and 11 a.m., gradually building up to burn about 1,600 calories per week through exercise. Over the 16-week program, researchers would measure changes in your body composition, fitness level, blood pressure, cholesterol, and eating behaviors through assessments like body scans, fitness tests, and questionnaires.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
United States