Intensive therapy to improve strength and movement in children with spinal muscular atrophy

This trial is testing whether a specialized intensive therapy program called HABIT-ILE combined with functional strength training can help children with spinal muscular atrophy (SMA) improve their movement, strength, and ability to do everyday activities. The therapy combines exercises that train both arms and legs together with targeted strength training, all delivered as a structured program. This approach has shown promise in children with other movement disorders, and researchers want to see if it can help children with SMA who are already receiving disease-modifying medications.

Although new medications have greatly improved outcomes for children with SMA, rehabilitation and physical therapy remain an important part of treatment. However, there is limited research on the best ways to combine intensive therapy with these newer medications, and scientists want to develop evidence-based exercise programs that can help children with SMA reach their full potential.