Plain-English translation of NCT07488897 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This is a two-part research study testing a new nasal spray called . The first part checks whether the medication is safe and well-tolerated in healthy people and people with asthma. The second part tests whether this treatment can help prevent asthma from getting worse when people catch a common cold virus.
Many people with asthma find that their symptoms get much worse when they catch a cold or other respiratory infection, and current treatments don't always prevent this. Researchers are testing whether this medication might help prevent or reduce that kind of asthma flare-up triggered by viral infections.
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In Part A, you will receive either the new medication or a placebo as a nasal spray in your nose, starting with a single dose and then potentially receiving repeat doses over time. In Part B, after taking the medication or placebo regularly for a period, you will be given a small amount of a cold virus (rhinovirus) through your nose to see how well the treatment protects you during a controlled cold. Throughout the study, you will have breathing tests, blood tests, and regular check-ins with the research team to monitor your safety and how you're responding to the treatment.
AI-generated summary from trial data · Sep 16, 2026 · Not medical advice
United Kingdom