Recruiting

Testing a Two-Drug Combination for Advanced Kidney Cancer

Plain-English translation of NCT07489495 on ClinicalTrials.gov ↗ · Source last updated September 2026 · Translation generated August 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This study is testing whether combined with a new medication called works better than alone for people with advanced kidney cancer. Both groups will take one pill by mouth once a day for about 2 years. Researchers want to see if adding the new medication helps people live longer and keeps their cancer from getting worse.

Many people with advanced kidney cancer stop responding to standard treatments like immunotherapy and other targeted drugs. This trial is looking for a better combination to help patients whose cancer has continued to grow despite previous treatments.

Do you qualify?

You likely qualify if…

you have been diagnosed with advanced, unresectable kidney cancer with clear cell features (Stage IV)
you have received no more than 3 prior systemic treatments for your kidney cancer
you have received only 1 prior immunotherapy drug targeting PD-1 or PD-L1
you have measurable disease that can be tracked on imaging scans
your cancer has progressed after previous treatments with immunotherapy and/or targeted therapy

You likely don't qualify if…

you have significant lung or heart disease, including a low oxygen level at rest or need for supplemental oxygen
you have had a heart attack, stroke, or serious heart condition in the past year
you have a blood clot that is not stable or being treated with blood thinners
you have had major surgery within the past 8 weeks or have not recovered from surgery
you have active lung inflammation, HIV infection, hepatitis B or C, or another cancer being treated

What participation looks like

You will be randomly assigned to take either the two-medication combination or one medication plus a placebo pill, both taken once daily by mouth. You will visit the research clinic regularly for about 2 years to have blood tests, imaging scans, and check-ups so the research team can monitor how well the treatment is working and watch for any side effects. The study will track how long you live and whether your cancer stays controlled.

AI-generated summary from trial data · Aug 25, 2026 · Not medical advice

Testing a Two-Drug Combination for Advanced Kidney Cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(92 sites)