Plain-English translation of NCT07489521 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether a gel implant called Arthrosamid works better than the standard steroid injection currently used to treat knee osteoarthritis pain. You would receive a single injection into your knee, and researchers would follow you for 18 months with imaging and check-ups to see which treatment helps more. Both treatments are delivered as injections directly into the knee joint.
Knee osteoarthritis causes pain and stiffness that can make daily life difficult, and current steroid injections only provide temporary relief. Researchers want to know if this newer gel medication can provide longer-lasting comfort and better function for patients who want to avoid surgery.
You likely qualify if…
You likely don't qualify if…
You would come in for a single knee injection—either the gel implant or a steroid injection—and you wouldn't know which one you received. After that, you would return for follow-up visits at 3, 6, 12, and 18 months where you'd have imaging scans (MRI) and answer questions about how your knee feels and functions. The whole study lasts about a year and a half, and your main time commitment is the follow-up appointments.
AI-generated summary from trial data · Jul 20, 2026 · Not medical advice
Ireland
Phase
Post-approval monitoring
Sponsor
Cappagh National Orthopaedic Hospital
Collaborators
Contura
Enrollment target
~200 participants
Started
January 2026
Primary completion
September 2027
Age range
18 Years – 100 Years
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
SEAN TEE LIM, M.D
Cappagh National Orthopaedic Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.