Plain-English translation of NCT07489547 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Heart Failure research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
When heart failure improves after treatment, doctors typically recommend patients keep taking all their medications — but this may mean taking more pills than necessary. This trial is testing whether stopping a medication called a mineralocorticoid receptor antagonist (MRA) is safe in patients whose heart function has recovered significantly. The study will compare patients who stop the medication with those who continue it, to see if their hearts remain stable.
Many heart failure patients are on multiple medications, which can make treatment difficult to stick with and increase the risk of side effects. However, doctors aren't sure whether patients whose hearts have recovered really need to keep taking all of their original medications, or whether some can be safely stopped. This trial will help answer that question.
You likely qualify if…
You likely don't qualify if…
If you qualify and enroll, you will be randomly assigned to either continue your current medications or to stop taking one specific medication (while keeping your other heart failure drugs). You will then be monitored closely with regular clinic visits and heart function tests to see how your heart responds. The study will track whether your heart stays stable, improves, or worsens over time.
AI-generated summary from trial data · Jul 19, 2026 · Not medical advice
Brazil