Recruiting

Testing a gentler stem cell transplant approach for blood cancers

Plain-English translation of NCT07493538 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a stem cell transplant procedure designed to be gentler on your body than traditional approaches. You would receive two chemotherapy medications called and to prepare your body, followed by healthy stem cells from a donor (a family member or matched unrelated donor). After the transplant, you'll also receive a medication called cyclophosphamide and other drugs to help prevent complications.

Standard stem cell transplants can be very hard on the body and cause serious side effects. This trial is testing whether using lower doses of preparation medications makes the treatment safer and more tolerable while still being effective against blood cancers.

Do you qualify?

You likely qualify if…

you are between 2 and 75 years old
you have been diagnosed with acute myeloid leukemia, myelodysplastic syndrome, or acute leukemia
you are healthy enough for transplant (with acceptable heart, lung, liver, and kidney function)
you have a donor available—either a family member match, an unrelated matched donor, or a partially matched family member
you are able to handle the physical demands of the procedure (measured by a performance score)

You likely don't qualify if…

you are pregnant or breastfeeding
you have an untreated or uncontrolled HIV infection
you have an active serious infection that hasn't been treated
you have active cancer in your central nervous system (brain or spinal cord)
you have received a previous stem cell transplant within the last 3 months

What participation looks like

You would be admitted to the hospital for several weeks. First, you'll receive chemotherapy medications to prepare your body for the transplant. Then you'll receive the donor stem cells through an IV infusion. After that, you'll stay in the hospital and be closely monitored as your new immune system develops, with frequent blood tests and check-ins. You'll continue taking medications at home for several months to prevent complications and monitor your recovery.

AI-generated summary from trial data · Jun 18, 2026 · Not medical advice

Trial locations(1 site)

United States

Masonic Cancer Center at University of Minnesota, Minneapolis, Minnesota