Plain-English translation of NCT07495904 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing how GLP-1 receptor agonists (a newer class of weight loss medication) affect body composition in adults with obesity, and whether eating a high-protein diet can help preserve muscle mass during treatment. Weight loss is important, but losing muscle along with fat can slow your metabolism and make it harder to keep weight off long-term. This study wants to find out if combining the medication with extra protein helps you lose fat while keeping your muscles strong.
While this medication is very effective at helping people lose weight, some people lose a significant amount of muscle tissue along with fat, which can be harmful to long-term health and fitness. Researchers want to know whether eating more protein alongside the treatment can protect your muscles and lead to better, longer-lasting results.
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You will be randomly assigned to receive the weight loss medication either with a standard Mediterranean-style diet or with a high-protein diet plan tailored just for you. You'll work with the research team on your nutrition, attend regular visits to track your weight and muscle mass using special body composition measurements, and follow your assigned eating plan. The study focuses on seeing how your body changes over time—specifically how much fat you lose versus muscle you preserve.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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