Plain-English translation of NCT07497347 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether L-serine, an amino acid supplement, can help older adults with depression improve their mood and thinking abilities. Researchers will compare people taking L-serine to those taking a placebo (a pill with no active ingredient) over 48 weeks. The study will measure changes in depression symptoms, memory, brain activity, and certain biological markers to understand how the medication might work.
Depression in older adults is common and can be hard to treat with standard medications alone. This medication may offer a new way to help improve both mood and brain function by supporting how the brain works at a biological level.
You likely qualify if…
You likely don't qualify if…
You will visit the research center three times over 48 weeks: at the start, after 18 weeks, and at the end. At each visit, you'll answer questions about your mood and thinking, complete memory tests, have your brain activity measured with electrodes, and provide blood, urine, and stool samples. Between visits, you'll take either the supplement or placebo daily as an oral stick mixed into water or food.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Italy
IRCCS Centro San Giovanni di Dio Fatebenefratelli
Enrollment target
~84 participants
Started
March 2026
Primary completion
June 2028
Age range
65 Years – 85 Years
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Moira Marizzoni, PhD
IRCCS Centro San Giovanni di Dio Fatebenefratelli
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.