Plain-English translation of NCT07499271 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This clinical trial is testing a personalized approach to treating newly diagnosed diffuse large B-cell lymphoma (DLBCL), a type of blood cancer, in patients whose cancer cells have a TP53 mutation. All participants will receive a chemotherapy combination called . Some patients will also receive an additional medication called , depending on their specific genetic subtype—the goal is to match the treatment to each person's unique cancer profile to improve results.
Standard chemotherapy works for some patients with this type of blood cancer, but not all. By identifying genetic subtypes and adding targeted medications that work against those specific genetic changes, doctors hope to achieve better outcomes and help more patients overcome this disease.
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You will receive treatment in two phases over about five months. First, you'll receive six cycles of chemotherapy (each cycle is 21 days), with some patients also taking an oral medication daily during this period based on their cancer's genetic subtype. Then you'll continue with two additional cycles of a supportive medication. Throughout the study, you'll have regular blood tests, imaging scans, and doctor visits to monitor your response to treatment and manage any side effects.
AI-generated summary from trial data · Aug 5, 2026 · Not medical advice
China
Phase
Testing effectiveness
Sponsor
The First Affiliated Hospital of Soochow University
Enrollment target
~35 participants
Started
January 2026
Primary completion
December 2027
Age range
18 Years – 70 Years
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Changju Qu
The First Affiliated Hospital of Soochow University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.