Plant-based nutrients and brain health in midlife women with obesity

This trial is testing whether a personalized daily powder formula containing inulin (a plant fiber), resveratrol, and quercetin (plant compounds) can help protect brain health in women during the perimenopausal transition who are living with overweight or obesity. The medication works by changing the balance of bacteria in your gut, which scientists believe may reduce inflammation in both your body and brain. Half of participants will receive the active formula, and half will receive a placebo powder with no active ingredients, over six months.

Women with obesity face a higher risk of memory loss and dementia, especially during midlife hormonal changes. Recent research suggests that what we eat can change our gut bacteria in ways that reduce harmful inflammation and protect the brain, but we need more evidence from human studies to understand how this works and whether it actually helps.