Plain-English translation of NCT07510438 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This is one of the first times this treatment has been tested in people.
This trial is testing a new medical device called Pulse Intravascular Lithotripsy (or Pulse IVL) designed to treat coronary artery disease—a condition where calcium and plaque build up in the heart's blood vessels. The device uses sound wave energy to gently break apart the hard calcium deposits that clog arteries, helping to restore normal blood flow to the heart. This is an early-stage study with a small group of patients to make sure the treatment is safe and works as intended.
Many heart patients have calcium buildup in their arteries that makes them very stiff and hard to treat with standard balloon angioplasty alone. This trial exists to see if this new treatment can safely and effectively open these heavily calcified arteries and help the vessel walls become more flexible again.
You likely qualify if…
You likely don't qualify if…
If you are selected, you will undergo a procedure in which doctors use a thin catheter to thread the Pulse IVL device through your blood vessels to the blocked area of your heart artery. The device will deliver sound wave pulses to break up the calcium deposits, followed by a balloon to help open the artery. You will be monitored closely during and after the procedure, with follow-up visits to track how well the treatment is working and check for any side effects.
AI-generated summary from trial data · Aug 29, 2026 · Not medical advice
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