Testing a new injection for hepatitis B virus infection

Plain-English translation of NCT07511218 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This is an early-stage clinical trial testing a new medication called . The study will first give the medication to healthy volunteers to make sure it's safe, and then test it in people living with chronic hepatitis B to see if it works and how well it's tolerated. Researchers want to understand how the medication moves through your body and whether it can help control the hepatitis B virus.

Chronic hepatitis B is a serious long-term liver infection that affects millions of people worldwide. Current treatments help many patients, but scientists are looking for new options that might work better or offer additional benefits to people who need them.

Do you qualify?

You likely qualify if…

you are between 18 and 55 years old (if healthy) or 18 and 65 years old (if you have hepatitis B)
you have a normal weight range (BMI between 18–28 if healthy, or 18–32 if you have hepatitis B)
you have been taking a stable hepatitis B medication for at least 6 months (if you have the disease)
you have undetectable hepatitis B viral levels (less than 100 IU/mL) at the time of screening
you are willing to use effective birth control for at least 6 months after receiving the medication

You likely don't qualify if…

you are currently enrolled in another clinical trial or have been in one within the past 3 months
you have advanced liver disease symptoms such as fluid buildup in the belly, bleeding from the stomach, or hepatic encephalopathy
you have a history of hepatocellular carcinoma (liver cancer) or suspect you may have it
you are pregnant, breastfeeding, or unwilling to use birth control during the study
you have received certain older hepatitis B therapies like interferon within the past 12 months

What participation looks like

If you're accepted as a healthy volunteer, you'll receive one or more injections of the medication or placebo and have blood tests and heart monitoring to check for safety. If you have hepatitis B, you'll continue your regular hepatitis B medication while also receiving the new medication (or placebo) by injection at multiple visits over several months, with regular blood tests to measure your viral levels and how your body responds. All participants will have follow-up visits to monitor for any side effects.

AI-generated summary from trial data · Jun 15, 2026 · Not medical advice

Trial locations(1 site)

China

AusperBio Investigational Site, Ch’ang-ch’un, Jilin