Plain-English translation of NCT07515521 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is testing whether a new vision test called fundus-tracked dark adaptometry — which measures how quickly your eyes adjust to darkness — can help doctors detect early changes in age-related macular degeneration (AMD). The researchers will also examine blood samples, genetic information, and detailed eye imaging to understand what causes delayed dark adaptation and to find better ways to test for early AMD.
Currently, doctors can only treat AMD once it has progressed to advanced stages. This study exists to develop better tests that can detect AMD much earlier, so that new treatments can be studied and given to patients before serious vision loss occurs.
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If you are healthy, you will visit the study site twice — once at the start and once two months later. If you have early or intermediate AMD, you will come three times: at the start, two months later, and then at 18 months. At each visit, you will undergo the new dark adaptation vision test, have your eyes scanned with imaging machines, and provide a blood sample. The visits will take several hours, and you'll be asked to sit in a dark room for part of the testing to measure how your eyes adjust.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
Germany
Sponsor
Maximilian Pfau
Enrollment target
~150 participants
Started
February 2026
Primary completion
December 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in April 2026.
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Central contact
Maximilian Pfau, MD, FEBO
Maximilian Pfau
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