Plain-English translation of NCT07517042 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether , a weight-loss medication, a structured lifestyle program, or a combination of both can help people maintain weight loss over the long term. The trial starts with 16 weeks of intensive treatment to help you lose weight, then tests different maintenance strategies for the following year to see which approach works best at keeping the weight off.
Weight loss is hard to maintain over time, and it's unclear whether people should stay on medication long-term, focus on lifestyle changes, or use both together. This trial will provide clear evidence to help doctors recommend the best strategy for keeping weight off for good.
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You'll first receive 16 weeks of intensive treatment with the medication at full dose to help you lose weight. After that initial phase, you'll be randomly assigned to one of four groups for the next year: receiving a placebo with lifestyle coaching, continuing the medication at a lower dose, combining the lower dose medication with lifestyle coaching, or receiving standard health education. Throughout the 2-year study, you'll have regular visits to check your progress, discuss your eating and exercise habits, and monitor how well you're maintaining your weight loss.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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