Testing vaginal fluid DNA markers to detect endometrial cancer early

Researchers at Mayo Clinic are studying whether women would accept a new way to detect endometrial cancer early using DNA markers found in vaginal fluid. Right now, endometrial cancer is often discovered late, which makes treatment harder. This study wants to understand how women—especially Black women, who face higher rates of this cancer—feel about using this simple, non-invasive test as an early-detection tool.

Endometrial cancer is sometimes diagnosed at a later stage when it's harder to treat. Researchers believe a simple vaginal fluid test could catch the disease much earlier, but they first need to know whether women would actually use it. This study helps them understand the real-world acceptability of this new approach.