Plain-English translation of NCT07527195 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing three medications—CagriSema (a combination of two new drugs), alone, and (a medication already approved for weight loss and diabetes)—to see how they affect your muscle health as you lose weight. Researchers want to understand whether these treatments help preserve or improve muscle strength and function during weight loss, not just reduce weight overall. You'll receive one injection per week for up to a year, and some participants will receive a placebo (an inactive injection) to compare results.
When people lose weight quickly, they often lose muscle along with fat, which can make them weaker and less mobile. This trial exists to see whether these new medications can help people lose fat while keeping their muscles healthy and strong—something that matters especially as we age.
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You will visit a research clinic regularly over about 15 months. You'll receive one injection under the skin each week for up to 52 weeks—either the new medication being tested, , or a placebo. Researchers will measure your muscle strength, body composition (how much is muscle versus fat), and how your muscles respond to blood sugar changes. You'll likely have blood tests and muscle function assessments to track how the treatment affects your health as you lose weight.
AI-generated summary from trial data · Jul 13, 2026 · Not medical advice
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