Plain-English translation of NCT07528274 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a combination of three treatments for people with advanced non-small cell lung cancer whose cancer has grown after their first round of immunotherapy and chemotherapy. The combination includes microwave ablation (a procedure that uses heat to destroy cancer tissue), (an immunotherapy medication that helps your immune system fight cancer), and (a chemotherapy drug). The goal is to see if this combination approach can slow or stop the cancer from growing.
When advanced lung cancer stops responding to initial immunotherapy and chemotherapy, patients need new treatment options. This trial is exploring whether adding a heat-based procedure to a new medication combination might help people whose cancer has already progressed despite first-line treatment.
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You would receive the heat treatment procedure as part of your care while also receiving the two medications intravenously every 3 weeks. The chemotherapy medication would typically be given for 4 to 6 cycles of treatment. You would need to attend regular study visits for blood tests, imaging scans to track your cancer, and check-ins with your care team to monitor how you're responding and manage any side effects. The trial is looking for about 20 participants total.
AI-generated summary from trial data · Jun 30, 2026 · Not medical advice
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