Targeted Radiation Before Stem Cell Transplant for Blood Cancers

Plain-English translation of NCT07532824 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This trial is testing proton-based total marrow irradiation (a specialized form of radiation therapy) combined with standard chemotherapy before a stem cell transplant in patients with serious blood cancers. The goal is to improve outcomes by targeting radiation directly to the bone marrow where cancer cells live, while reducing damage to healthy organs around it. This approach may help prevent cancer from coming back while causing fewer side effects than traditional radiation methods.

Many patients with advanced leukemia or myelodysplastic syndrome don't do well with standard stem cell transplants because the cancer returns or the treatment itself causes serious harm. Researchers believe that this specialized type of radiation can deliver stronger cancer-fighting power while sparing the heart, lungs, kidneys, and liver from unnecessary radiation exposure.

Do you qualify?

You likely qualify if…

you have been diagnosed with acute myeloid leukemia (AML) that has come back after treatment, resisted chemotherapy, or is high-risk even in remission
you have been diagnosed with myelodysplastic syndrome (MDS) that is high-risk or has increased cancer cells despite prior treatment
you are between 18 and 65 years old
you have been approved by your transplant center as a good candidate for stem cell transplant
you are able to understand the study and provide written informed consent

You likely don't qualify if…

you have moderate to severe heart, kidney, or liver disease
you have significant lung function problems
you have a current or prior diagnosis of HIV or active hepatitis
you have cirrhosis of the liver
you are pregnant or breastfeeding

What participation looks like

You will receive specialized radiation therapy to your bone marrow combined with chemotherapy drugs as preparation for your stem cell transplant. Depending on your age and overall health, you'll receive one of two chemotherapy combinations alongside the radiation. After completing this conditioning regimen, you'll receive the stem cell transplant itself. The study involves standard transplant center visits and monitoring, including blood tests and imaging, similar to any stem cell transplant program.

Targeted Radiation Before Stem Cell Transplant for Blood Cancers

What is this trial?

Do you qualify?

What participation looks like

Trial locations(2 sites)