Plain-English translation of NCT07537361 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a leucine-restricted diet—a temporary eating plan that limits a specific amino acid—can help improve how well standard cancer treatment works for people with advanced stomach cancer. All participants receive four cycles of chemotherapy combined with Sintilimab, an immunotherapy medication that helps your immune system fight cancer. The key difference is that some participants follow a special restricted diet for 3 days during each treatment cycle, while others eat normally throughout.
Researchers believe that limiting leucine, a building block of protein, might help the body respond better to chemotherapy and immunotherapy by changing how cancer cells use nutrients. This trial will test whether this dietary approach makes the treatment more effective and safer for people with advanced stomach cancer.
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You will receive four cycles of chemotherapy combined with immunotherapy over several months. If you are in the diet group, during each 3-day period at the start of every cycle, you will follow the leucine-restricted diet (likely a special nutritional powder or carefully planned meals), then return to normal eating for the rest of that cycle. The control group eats normally throughout. Your doctors will monitor your health, check how well the treatment is working, and watch for side effects at regular visits.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
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