Ear acupressure plus steroid to prevent nausea from breast cancer treatment

This trial is testing a combination approach to prevent nausea and vomiting in breast cancer patients receiving trastuzumab deruxtecan, a powerful targeted therapy. The study combines a traditional Chinese medicine technique—applying small seeds to specific points on your ear—with a steroid medication called dexamethasone. The goal is to reduce severe nausea while avoiding the extra side effects that come from using multiple strong anti-nausea drugs.

Most patients receiving this medication experience significant nausea and vomiting, and the standard way to prevent it uses four different types of drugs that can cause their own problems like constipation and loss of appetite. Researchers want to find a gentler way to prevent these symptoms while protecting your overall quality of life and ability to continue treatment.