Plain-English translation of NCT07546552 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers are testing whether denosumab, a medication already approved to treat osteoporosis (weak bones), might also help improve fertility in women. The study focuses on a natural signaling system in the ovaries that affects how eggs develop. By blocking this signaling pathway with the medication, researchers hope to improve egg maturation and potentially help women achieve pregnancy.
Current fertility treatments don't work equally well for all women, especially as they get older. Laboratory studies suggest this medication could help eggs mature better and offset some effects of aging on the ovaries, but this hasn't been tested in women yet.
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Participants will receive either the medication being tested or a placebo (inactive treatment) as part of their fertility treatment cycle. The study will track how their eggs develop and mature, and measure certain markers in the fluid surrounding the eggs to see if the medication makes a difference. The research team will follow up to see if the treatment affects fertility outcomes.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
Denmark
Sponsor
Peter Humaidan
Collaborators
Herlev Hospital
Enrollment target
~100 participants
Started
August 2025
Primary completion
March 2028
Age range
18 Years and older
Sex
Female only
Last updated on clinicaltrials.gov in April 2026.
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