Natural killer cell therapy for advanced brain tumors

Plain-English translation of NCT07552233 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing NK cell therapy — a treatment that uses your own immune cells to fight brain cancer. Researchers will give you these specially prepared cells both directly into your brain and through your bloodstream, in increasing doses, to find the safest and most effective amount. The goal is to see if this approach can help people whose brain tumors have stopped responding to standard treatments like chemotherapy or radiation.

Many patients with advanced brain tumors like glioblastoma run out of treatment options when standard therapies stop working. This medication offers a completely different approach by harnessing the body's own immune system to target cancer cells, which may help people who have exhausted conventional options.

Do you qualify?

You likely qualify if…

you are between 18 and 70 years old
you have been diagnosed with a malignant brain tumor (such as glioblastoma or brain metastasis) that has grown or come back after standard treatment
you completed your last chemotherapy or radiation at least 4 weeks before joining the trial
you are in reasonably good overall health, able to have an MRI scan, and expected to live at least 4 weeks
your blood counts and organ function are within acceptable ranges as checked by blood tests

You likely don't qualify if…

you have active hepatitis B or C, HIV, or an untreated infection
you are pregnant, breastfeeding, or planning to become pregnant during the trial
you have severe organ damage or uncontrolled medical problems
you have had an organ transplant or are waiting for one
you have allergies to immunotherapy or cell-based treatments

What participation looks like

You will receive infusions every 2 weeks: one injection directly into or near your brain tumor, and one intravenous infusion (through your arm). The trial starts with lower doses and gradually increases to find the right amount for your body. You'll have regular MRI scans and blood tests to monitor how the treatment is working and check for any side effects. The study involves 27 patients total and is still recruiting participants.

AI-generated summary from trial data · Jun 7, 2026 · Not medical advice

Trial locations(4 sites)

China

Peking University Third Hospital, Beijing, Beijing Municipality

Qinhuangdao Runze Hospital, Qinhuangdao, Hebei

Zhengzhou Second Hospital, Zhengzhou, Henan

Henan Academy of Innovations in Medical Science, Zhengzhou, Henan