Testing a pain medication for bowel symptoms when Crohn's is controlled

Plain-English translation of NCT07556718 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing whether , a medication commonly used to treat irritable bowel syndrome and abdominal pain, can safely reduce ongoing stomach pain, bloating, and bowel habit changes in adults whose Crohn's disease is in remission. Even when Crohn's inflammation is controlled with current treatments, many patients continue to experience uncomfortable digestive symptoms. This study will compare the medication to a placebo to see if it actually helps.

Many people with Crohn's disease continue to suffer from abdominal pain and bowel problems even after their inflammation is successfully managed. This medication has worked well for similar symptoms in other conditions, so researchers want to test whether it could help this specific group of patients.

Do you qualify?

You likely qualify if…

you are between 18 and 65 years old
you have been diagnosed with Crohn's disease and your disease has been in remission for at least 3 months
you have recent test results (blood work, colonoscopy, or imaging) showing your disease is well-controlled
you experience abdominal pain or discomfort at least 3 days per month and have irregular bowel patterns, even though your inflammation is controlled
you have been on stable Crohn's medication for at least 90 days with no planned changes
you have had a heart rhythm test (ECG) in the past year showing normal results

You likely don't qualify if…

you currently have signs of active Crohn's disease inflammation based on recent tests or colonoscopy
you have been hospitalized for a Crohn's flare or bowel obstruction in recent months
you have a draining fistula, abscess, or other serious active infection related to your Crohn's disease
you have had significant changes to your Crohn's medications in the past 90 days or plan to change them during the study
you have a known heart rhythm problem or abnormal ECG results

What participation looks like

You would be randomly assigned to either take the study medication or a placebo (dummy pill). If you receive the medication, you would start at a low dose and gradually increase it over time as tolerated, up to 50 mg per day. You would complete questionnaires about your symptoms and bowel habits using a secure online platform, and you would have remote check-ins with the research team to monitor how you're doing and watch for any side effects.

AI-generated summary from trial data · Jun 11, 2026 · Not medical advice

Trial locations(1 site)

United States

University of Michigan, Ann Arbor, Michigan