Take a medication designed to prevent brain artery narrowing after stroke

Back to Intracranial Atherosclerotic Disease (ICAD) trials

Recruiting

What is this trial?

This trial is testing whether a medication called can help prevent the narrowing of arteries inside your brain from getting worse after a stroke or transient ischemic attack (TIA, also called a mini-stroke). If you qualify, you'll be randomly assigned to either take this medication for 12 months along with your regular stroke care, or to continue with standard care alone. Researchers want to see whether the medication can slow the progression of brain artery narrowing and improve your cholesterol and triglyceride levels.

People who have had a stroke caused by narrowed brain arteries and who also have high triglyceride levels face a significant risk of having another stroke or their condition worsening. Current standard treatments don't always prevent this progression, so doctors are testing this medication to see if it offers additional protection.

Do you qualify?

You likely qualify if…

you have had a stroke or high-risk mini-stroke that is now stable, occurring between 24 hours and 3 years before enrollment
imaging scans show 50–99% narrowing in one of the arteries inside your brain
you have elevated triglyceride levels (fasting level of 150–499 mg/dL or non-fasting level of 175–499 mg/dL)
you are 18 years of age or older
you are able to give informed consent or have a legal representative who can consent for you

You likely don't qualify if…

your brain artery narrowing is caused by conditions other than atherosclerosis, such as vasculitis or arterial dissection
you have severe narrowing (70% or more) in the carotid artery in your neck
you are pregnant, might be pregnant, or are breastfeeding
you have severe liver disease, gallstones, or a history of pancreatitis related to high triglycerides
you have recently received clot-busting medication or mechanical thrombectomy (within 24 hours), or are scheduled for a procedure to open narrowed arteries

What participation looks like

You will be randomly assigned to either take daily for 12 months in addition to your regular stroke medications, or to continue with standard care alone. Throughout the study, you will have regular blood tests to check your triglyceride levels, kidney function, and liver health, as well as follow-up visits to monitor your condition. At the end of 12 months, imaging scans will be repeated to see whether the medication slowed any progression of brain artery narrowing.

Testing a medication to prevent worsening narrowing of brain arteries after stroke

What is this trial?

Do you qualify?

What participation looks like

Trial locations(37 sites)