Recruiting

Gold nanoparticles plus radiation therapy for advanced melanoma

Plain-English translation of NCT07562841 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated July 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This trial is testing a new combination approach for advanced melanoma that hasn't responded to standard treatments. Researchers are studying whether nanoparticles—tiny gold-based particles injected directly into tumors—can work together with radiation therapy and an immune-boosting drug called to help your body fight the cancer more effectively.

Advanced melanoma is hard to treat because tumors often resist radiation and the immune system struggles to recognize cancer cells. This trial exists to see whether this medication can overcome those barriers by making tumors more sensitive to radiation and helping your immune system recognize and destroy cancer cells.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with unresectable (inoperable) Stage III or Stage IV melanoma and have not received systemic (whole-body) cancer treatment before
you have at least one tumor accessible for injection and radiation that is located in the skin, under the skin, or in lymph nodes
your overall health status is good enough to tolerate the treatment (ECOG performance status 0 or 1)
your blood counts, kidney function, liver function, and heart function are adequate based on recent lab tests

You likely don't qualify if…

you have received prior treatment with anti-PD-1 or similar immune checkpoint inhibitor drugs
you have a known allergy to the gold nanoparticles or the immune therapy medication
you have active skin infection, ulceration, or bleeding at the site where the injection would be placed
you have certain genetic mutations in your melanoma (like BRAF, c-KIT, or NRAS) for which FDA-approved targeted therapies already exist
you have ocular (eye) melanoma or mucosal (inside-the-mouth) melanoma

What participation looks like

You would receive a single injection of the gold nanoparticles directly into one of your tumors using ultrasound or CT scan guidance. Over the following weeks, you would receive five doses of radiation therapy to that same tumor site. Once the injection and radiation are complete, you would begin receiving the immune-boosting medication () as systemic treatment. You'll have regular follow-up visits to monitor your response and check for any side effects.

AI-generated summary from trial data · Jul 3, 2026 · Not medical advice

Trial locations(2 sites)

China

West China Hospital, Sichuan University, Chengdu, Sichuan