Plain-English translation of NCT07572032 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
After heart surgery or procedures that fix valve problems or blocked arteries, doctors typically start patients on multiple heart medications right away, including sacubitril/valsartan and SGLT2 inhibitors. This trial is testing whether waiting to see how much your heart naturally recovers before starting these medications might be safer and just as effective—especially since removing the original problem (the blocked artery or faulty valve) does much of the healing work on its own.
The current heart failure guidelines were developed based on patients whose underlying heart problem couldn't be fixed. But when doctors successfully repair a valve or open a blocked artery, your heart often recovers significantly without any extra medications. Starting multiple medications immediately in these patients may expose them to unnecessary side effects and costs when waiting a few months might show that the medication isn't even needed.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to one of two groups: either start heart medications (sacubitril/valsartan and an SGLT2 inhibitor) right away after your surgery, or wait 6 months while doctors monitor your heart's natural recovery with regular heart imaging and check-ups. If your heart does not recover well during the waiting period, or if you develop worsening symptoms, you will start the medications immediately. Either way, you will be followed for a total of 12 months from the time you join the study.
AI-generated summary from trial data · Sep 20, 2026 · Not medical advice
South Korea
Age range
18 Years and older
Last updated on clinicaltrials.gov in September 2026.
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Central contact
Kyungsub Song, MD
Keimyung University Dongsan Medical Center
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