Comparing how pancreas cells work in younger versus older adults with type 2 diabetes

Plain-English translation of NCT07574138 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated July 2026 · How we translate trials

What is this trial?

This research study is trying to understand why some people develop type 2 diabetes at a younger age (before 40) compared to those who develop it later in life (at 40 or older). Researchers want to compare how the insulin-producing cells in the pancreas work differently between these two groups and how they change over a year of follow-up care.

Type 2 diabetes that starts early in life may behave differently than diabetes that develops later, but doctors don't fully understand these differences yet. This study aims to uncover how the pancreas cells function differently in younger people with diabetes, which could help doctors provide better, more personalized care in the future.

Do you qualify?

You likely qualify if…

you have been diagnosed with type 2 diabetes within the last 10 years
you are in one of two groups: diagnosed before age 40 OR diagnosed at age 40 or older
you have not needed insulin for at least 6 months and have never had diabetic ketoacidosis
for those diagnosed before age 40: your pancreas cells are still producing insulin (measured by C-peptide levels) and you don't have antibodies that indicate type 1 diabetes
you are willing to attend follow-up appointments over one year and provide blood samples

You likely don't qualify if…

you are pregnant or have an acute illness at the time of enrollment
you have type 1 diabetes or secondary diabetes caused by pancreatic disease, medications like steroids, or other endocrine disorders
you have severe kidney disease (eGFR less than 30)
you are taking medications that affect how pancreas cells work, such as high-dose steroids or immunosuppressive drugs
you are not of Vietnamese ethnicity or cannot reliably attend scheduled appointments

What participation looks like

You will visit the Endocrinology Clinic at University Medical Center Ho Chi Minh City for regular appointments over one year. During these visits, you'll have blood tests to measure how well your pancreas is controlling blood sugar and to track changes in your diabetes over time. The researchers will compare your results with the other group to see if there are differences in how the pancreas works based on when you were diagnosed with diabetes.

AI-generated summary from trial data · Jul 7, 2026 · Not medical advice

Trial locations(1 site)

Vietnam

University of Medicine and Pharmacy of Ho Chi Minh City, Ho Chi Minh City, Cho Lon Ward