Testing a new medication for moderate to severe inflammatory bowel disease

This trial is testing a new medication called JNJ-78934804 to see if it can better control moderate to severe ulcerative colitis—a chronic disease where the lining of the large intestine becomes inflamed and develops ulcers. Researchers will compare this medication to an existing approved treatment called guselkumab to find out which works better and is safer for patients like you.

While current treatments help many people with ulcerative colitis, some patients don't respond well enough to them, stop responding over time, or can't tolerate them. This trial aims to offer a new option that may work better for people whose disease isn't controlled by existing medications.