Predicting breathing tube removal success in severe lung disease

Plain-English translation of NCT07579052 on ClinicalTrials.gov ↗ ·

What is this trial?

Researchers are developing and testing a prediction model called CLEAR to help doctors know when patients with severe chronic obstructive pulmonary disease (COPD) are ready to stop using breathing machines. The study follows two groups of patients—one using a breathing tube and one using a face mask for support—and measures specific indicators like lung muscle strength, breathing patterns, and overall reserve capacity. The goal is to create a tool that reliably predicts who can successfully breathe on their own.

Removing patients from breathing machine support at the wrong time can be dangerous and lead to complications, but waiting too long also causes problems. This study aims to develop a reliable prediction tool so doctors can make safer, more confident decisions about when each patient is truly ready to breathe independently.

Do you qualify?

You likely qualify if…

you are 40 years old or older
you have been diagnosed with COPD or have a consistent clinical history of lung disease
you are in an intensive care unit receiving breathing machine support for acute respiratory failure
your medical team believes you may be ready to start the process of reducing breathing machine support
you are able to undergo muscle ultrasound imaging (your doctor will check this)

You likely don't qualify if…

you are under 40 years old
you have a neuromuscular disease that affects your breathing muscles
you have significant chest wall deformity or other restrictive lung conditions
you are currently hemodynamically unstable requiring high-dose blood pressure medications
you are unable to give informed consent or have a legal representative who cannot consent

What participation looks like

If you qualify, you will be enrolled in one of two groups depending on which type of breathing support you're receiving. During the time when your medical team assesses your readiness to come off breathing support, you will undergo specific breathing tests and muscle ultrasound imaging to measure your lung strength and breathing patterns. The research team will collect information about these measurements and track whether you can successfully breathe on your own afterward; the study does not change your medical care or treatment decisions.

Predicting breathing tube removal success in severe lung disease

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)