Testing new drug combinations before lung cancer surgery

Plain-English translation of NCT07586202 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated September 2026 · How we translate trials

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Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing , a new medication, combined with either another targeted drug or chemotherapy to shrink lung cancer before surgery. The study focuses on people with early-stage, resectable lung cancer that has a specific genetic change called an EGFR mutation. Researchers want to see if giving treatment before surgery can help improve outcomes.

Currently, people with early-stage lung cancer often have surgery first, sometimes followed by chemotherapy. This trial is exploring whether treating the cancer with medication beforehand might shrink the tumor, make surgery easier, and potentially improve long-term survival.

Do you qualify?

You likely qualify if…

you have been diagnosed with non-small cell lung cancer at stage II or IIIB with an EGFR mutation
your cancer is considered resectable, meaning doctors believe it can be completely removed by surgery
you have not received any prior chemotherapy, targeted therapy, or immunotherapy for lung cancer
you are in good overall health with an Eastern Cooperative Oncology Group performance status of 0 or 1
you are willing to have a biopsy if needed to confirm your tumor's genetic makeup

You likely don't qualify if…

you have a history of uncontrolled serious illness
you have or have had interstitial lung disease or pneumonitis (inflammation of the lung tissue)
you have an allergy or hypersensitivity to any of the study drugs or their ingredients
your cancer has other genetic mutations besides EGFR, such as ALK, MET, HER2, ROS1, NTRK, BRAF, RET, or KRAS
you have previously received systemic cancer treatment of any kind for lung cancer

What participation looks like

If you join this trial, you will receive the study medication by injection or infusion before your scheduled lung cancer surgery. You will be assigned to receive either combined with one targeted drug, or combined with chemotherapy. During the treatment period, you'll have regular clinic visits for exams, blood tests, and imaging scans to monitor how well the treatment is working. After completing the medication course, you'll proceed with your planned surgery to remove the cancer.

AI-generated summary from trial data · Sep 3, 2026 · Not medical advice

Testing new drug combinations before lung cancer surgery

What is this trial?

Do you qualify?

What participation looks like

Trial locations(20 sites)