Plain-English translation of NCT07589647 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a treatment called temporal interference stimulation (TIS)—a non-invasive electrical brain stimulation technique—to see if it can help improve metabolism and weight-related problems in people with bipolar disorder. Researchers will measure changes in key metabolic markers and study how this treatment affects the body's natural rhythms. Half the participants will receive active stimulation, and half will receive a milder sham (placebo) version.
Many people with bipolar disorder also struggle with obesity and metabolic problems, which can be harder to treat with standard medications. This trial explores whether targeted brain stimulation might address these metabolic issues and help improve overall health outcomes.
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If you join this study, you will receive electrical stimulation to a specific area of your brain (the suprachiasmatic nucleus) for 20 minutes at a time. The stimulation uses very mild electrical currents (adjusted to your individual needs) at specific frequencies. You will be randomly assigned to either receive active stimulation or a sham version, and researchers will monitor changes in your metabolism and metabolic markers over time.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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