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Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether minocycline, a common antibiotic, can help improve recovery in people who have had emergency treatment to remove a blood clot from the back of the brain (the posterior circulation). Half of participants will receive the medication, and half will receive a placebo (a dummy pill). Researchers want to see if the medication helps more people recover to independence after 3 months.
When a blood clot blocks blood flow to the back of the brain, emergency doctors can remove it with a procedure called thrombectomy. However, even after the clot is removed, the brain can continue to be damaged by inflammation and other processes. This study is testing whether this medication might reduce that damage and help people recover better.
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If you join this study, you will be randomly assigned to receive either the medication or a placebo immediately after your thrombectomy procedure. You will take either 9 doses of the treatment over 4 days (starting with one larger dose, then smaller doses twice daily), which can be taken by mouth or through a feeding tube if you have difficulty swallowing. The main follow-up visit will be at 90 days after your stroke to check how well you have recovered.
AI-generated summary from trial data · Jul 19, 2026 · Not medical advice
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