Recruiting

Testing a new medication for moderate to severe skin inflammation

Plain-English translation of NCT07604324 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

This is one of the first times this treatment has been tested in people.

What is this trial?

This is a first-in-human study testing an experimental medication called to see if it is safe and well-tolerated in people. The trial has two parts: first, researchers will give increasing doses of the medication to healthy volunteers to understand how the body processes it and watch for any side effects. Then, in the second part, people with moderate to severe atopic dermatitis will receive the medication to see if it helps improve their skin condition.

Atopic dermatitis is a serious skin condition that causes intense itching, inflammation, and discomfort, and many people don't get adequate relief from topical creams and ointments alone. This trial is testing whether this new medication could offer a better treatment option for people whose skin disease remains uncontrolled despite current therapies.

Do you qualify?

You likely qualify if…

you are between 18 and 55 years old (for the healthy volunteer part) or 18 or older (for the atopic dermatitis part)
you have been diagnosed with atopic dermatitis for at least one year that is not adequately controlled by topical treatments alone (for the atopic dermatitis part only)
your skin condition meets specific severity criteria, including a significant area of your body affected by atopic dermatitis and moderate to severe itching (for the atopic dermatitis part only)
you are willing to use highly effective birth control during the study and for about 6.5 months after stopping treatment (if applicable)

You likely don't qualify if…

you have taken another experimental drug within the last 30 days
you have a positive test for tuberculosis, HIV, syphilis, or hepatitis B or C
you have a history of immunodeficiency or untreated infections such as parasitic infections
you are a woman who could become pregnant and are unwilling to use highly effective contraception
you have an uncontrolled chronic medical condition such as uncontrolled diabetes, high blood pressure, heart disease, or severe obesity

What participation looks like

If you qualify, you will be randomly assigned to receive either the medication or a placebo (an inactive look-alike). For the healthy volunteer part, you will receive a single dose and then be monitored for safety and how your body processes the medication. For the atopic dermatitis part, you will receive multiple doses over time while researchers track how the medication affects your skin condition and watch for any side effects. Throughout the study, you will attend clinic visits where researchers will check your vital signs, perform blood tests, and assess your skin.

AI-generated summary from trial data · Jun 21, 2026 · Not medical advice

Trial locations(1 site)

Japan

Novartis Investigative Site, Fukuoka