Testing a new treatment to reduce heart artery plaque in people with high Lp(a)

This trial is testing a medication called lepodisiran to see if it can help reduce plaque buildup in the coronary arteries (the blood vessels that feed your heart) in people who have high levels of a protein called Lp(a). High Lp(a) increases your risk of heart disease, and this study will check whether the medication can actually shrink or prevent the plaque that builds up in these arteries. Researchers will use special imaging scans to measure the plaque before and after treatment.

People with very high Lp(a) levels are at much higher risk for heart attacks and strokes, even when taking other cholesterol medications. There aren't many treatment options specifically designed to lower Lp(a), so researchers are testing this medication to see if it can slow down or reverse the buildup of plaque in the heart's blood vessels.