Plain-English translation of NCT07614828 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial studied whether giving immunotherapy combined with chemotherapy before surgery could help people with a rare type of melanoma that starts in the nasal passages and sinuses. The immunotherapy helps your immune system fight cancer cells, while chemotherapy directly attacks them. The goal was to see if this combination treatment given before surgery would improve survival and outcomes.
This type of melanoma is very rare and has a very poor outlook. Doctors wanted to explore whether using the combination treatment before surgery—rather than just surgery alone—might help patients live longer and have better outcomes.
If you had qualified for this trial, you would have received immunotherapy combined with chemotherapy and radiation before undergoing endoscopic surgery (minimally invasive nasal surgery). The treatment plan would have aimed to shrink the tumor before surgery to improve the chances of complete removal. You would have had imaging scans and blood tests to monitor your response and ensure your body was tolerating the treatment well.
AI-generated summary from trial data · Jul 20, 2026 · Not medical advice
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