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Researchers want to understand why some people with chronic migraines that don't respond to standard treatments may benefit from placebo effects—the power of expectation and suggestion to reduce pain. This study will use advanced brain imaging and psychological assessments to compare people with hard-to-treat chronic migraines to healthy volunteers, looking for differences in how their brains are organized and how responsive they are to suggestions.
Many people with chronic migraines continue to suffer despite trying multiple preventive medications. Scientists believe that understanding which patients are more responsive to suggestion and expectation—and what's different about their brains—could help identify new ways to help people manage their pain and improve their daily lives.
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If you qualify, you will visit the research center for assessments that include advanced brain imaging scans (similar to an MRI) and a series of psychological questionnaires designed to measure how you respond to suggestions and expectations. The study is observational, meaning researchers will observe and measure your brain characteristics and psychological traits rather than giving you a new treatment to try. Your participation helps scientists build a better picture of why some people with treatment-resistant migraines might benefit from expectation-based approaches.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
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