Testing a new immune cell treatment for severe lupus

Plain-English translation of NCT07617740 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This is an early-stage trial testing a new treatment called , which uses specially modified immune cells to help control severe lupus in people whose disease has not responded well to other medications. The trial will enroll up to 18 people and test three different dose levels to figure out which dose works best and is safest. Researchers want to understand how well this treatment works and what side effects it might cause.

Some people with lupus don't improve enough with standard medications like steroids and immunosuppressants, and their disease continues to damage their organs. This trial exists to see whether this new immune cell therapy might help people whose lupus hasn't responded to other treatments.

Do you qualify?

You likely qualify if…

you are between 18 and 75 years old
you have been diagnosed with active, severe lupus that hasn't responded well to standard medications (steroids and at least two other types of lupus drugs)
you have had lupus confirmed by blood tests and have a formal diagnosis for at least 24 weeks
you have lupus antibodies in your blood (such as anti-nuclear antibody, anti-dsDNA, or anti-Smith antibodies)
your blood counts are healthy enough to participate (normal neutrophil, lymphocyte, red blood cell, and platelet levels)
your liver function is acceptable and you can commit to birth control for one year after the treatment

You likely don't qualify if…

you have drug-induced lupus rather than the typical form
you have other autoimmune diseases like Sjögren's syndrome, psoriasis, or rheumatoid arthritis that could interfere with the study
you have severe antiphospholipid syndrome or have had a catastrophic form of it in the past year
you have lupus affecting your nervous system with severe activity
you have an active fungal, viral, or bacterial infection that hasn't improved with treatment

What participation looks like

You would receive a single infusion of the medication at one of three dose levels; researchers will start with the lowest dose and gradually increase it as they learn it's safe. You will be closely monitored for safety, with blood tests and evaluations to track how your lupus responds and whether you experience any side effects. The study will follow you over time to understand how long the treatment's effects last and how your body responds to it.

AI-generated summary from trial data · Jun 5, 2026 · Not medical advice

Trial locations(1 site)

China

Peking University People's Hospital, Beijing

Testing a new immune cell treatment for severe lupus

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)

Key details

Contact the research team directly

Interested in joining?