Plain-English translation of NCT07628127 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This is one of the first times this treatment has been tested in people.
This is a first-in-human study testing two new oral medications called and (ecnoglutide) designed to help with weight management. Researchers want to understand how safe these medications are, how well people tolerate them, and how the body processes them. You would receive either one medication alone, both medications together, or a placebo (inactive pill).
Currently, treatment options for overweight and obesity are limited. This trial exists to explore whether this new oral medication—or combination of medications—could offer a safe and effective way to help people manage their weight without the need for injections.
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You would participate in one of three parts of the trial: a single-dose phase where you take the medication (or placebo) once, or a multiple-dose phase where you take it weekly or daily for several weeks. You'll have regular visits to the research clinic for check-ups, blood tests, and heart monitoring to ensure the medication is safe. The entire trial involves screening visits, dosing visits, and follow-up visits to monitor how your body responds.
AI-generated summary from trial data · Aug 30, 2026 · Not medical advice
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