How antibiotics work in cystic fibrosis patients on newer therapy

This study is investigating how antibiotics work in people with cystic fibrosis who are being treated with elexacaftor/tezacaftor/ivacaftor (ETI), a newer combination therapy that significantly improves lung function and overall health. The researchers want to measure antibiotic levels in the blood during treatment for lung infections to see whether this medication changes how the body handles antibiotics. Understanding this could help doctors give better antibiotic doses in the future.

Cystic fibrosis has traditionally required higher antibiotic doses because the disease changes how the body absorbs and processes these medications. Now that this newer treatment has dramatically improved CF patients' health and lung function, doctors don't know yet whether antibiotic dosing needs to change — this study will help answer that question and ensure patients get the most effective and safest treatment possible.