Recruiting

Internal radiation seeds to treat recurrent gynecologic cancer

Plain-English translation of NCT07631572 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated September 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial studies cesium-131 low-dose rate brachytherapy, a form of internal radiation therapy, for treating cervical and endometrial cancer that has returned in the vagina after previous pelvic radiation. In this treatment, grain-of-rice-sized radioactive seeds are implanted directly into or near the tumor to kill cancer cells. The seeds give off radiation for a short time—most is gone within a few weeks—and then become inactive, though they remain in your body permanently.

When cervical or endometrial cancer comes back in the vagina after radiation, the only currently available cure is a major operation that removes many pelvic organs and carries serious side effects. This trial exists to see if this treatment can offer patients an effective way to treat recurrent cancer while preserving their organs and avoiding major surgery.

Do you qualify?

You likely qualify if…

you have been diagnosed with endometrial or cervical cancer that has returned in the vagina
you previously received pelvic radiation therapy for your original cancer
your recurrent cancer is measurable (at least 1 cm) on imaging or physical examination
you are in good enough health to tolerate this treatment (performance status 0, 1, or 2)
you are willing and able to sign an informed consent form

You likely don't qualify if…

you have another active cancer or were diagnosed with a different cancer in the past three years
you have cancer that has spread to distant sites or regional lymph nodes
you are pregnant or unwilling to use two forms of birth control during and for two months after treatment
you have a history of severe allergic reactions to similar compounds or agents used in this study
you received epoetin alpha (a blood-stimulating medication) within one month before screening

What participation looks like

You would undergo a procedure in which radioactive cesium-131 seeds are implanted directly into or near your recurrent tumor in the vagina. The seeds deliver radiation to kill cancer cells over a short period, with most radiation dissipating within a few weeks. You will likely have follow-up visits to monitor how well the treatment works and manage any side effects, though the exact schedule will depend on your doctor's assessment.

Internal radiation seeds to treat recurrent gynecologic cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)