Take an experimental oral insulin medication compared to standard insulin injections

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What is this trial?

This trial is testing a new medication called SCD0503—an insulin pill that you swallow instead of inject. Researchers want to see how well this medication works compared to regular insulin injections, how your body absorbs it, and whether eating food affects how it works. The active ingredient is regular human insulin, which has been safely used in diabetes treatment for many years.

Currently, people with type 1 diabetes must inject insulin multiple times a day. This trial exists to see if an oral (pill) version could work just as well, which might make diabetes management easier and less painful for patients.

Do you qualify?

You likely qualify if…

you are a male between 18 and 64 years old
you have been diagnosed with type 1 diabetes for at least 12 months
you have a healthy weight (BMI between 18.5 and 29.9)
your blood sugar has been relatively stable on your current insulin routine for at least 2 months
your blood sugar control is reasonably good (HbA1c of 8.5% or lower)

You likely don't qualify if…

you have serious eye problems from diabetes (proliferative retinopathy or maculopathy) or nerve damage in your limbs
you have had more than one severe low blood sugar episode with seizures or loss of consciousness in the past 6 months
you have been hospitalized for diabetic ketoacidosis in the past 6 months
you have hepatitis B or C, or HIV
you smoke more than 5 cigarettes per day or have a significant history of alcohol or drug abuse

What participation looks like

You will visit the research clinic 8 times over 1 to 4 months. During most visits, you'll receive either the new medication or a standard insulin injection, then have your blood sugar monitored closely using a special device called a 'clamp' that keeps your blood sugar stable, or you'll eat a standard breakfast and have your blood sugar measured afterward. You'll have catheters (small tubes) placed in your arms to take blood samples and give you glucose or insulin if needed during the visits. Different participants will receive the treatments in different orders to help researchers understand how the medication works.

Testing a new pill form of insulin for type 1 diabetes

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)