Plain-English translation of NCT07638007 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research is studying how targeted therapies (called TKIs) used to treat chronic leukemias affect thinking, memory, and concentration. Researchers want to understand whether people experience cognitive changes while taking these medications, and how those changes develop over time. By comparing people receiving the medication with healthy volunteers, they hope to learn more about this side effect and eventually help future patients manage it better.
Some people taking targeted leukemia medications report problems with memory, focus, or thinking—a condition called cancer-related cognitive impairment. This study exists because doctors need better information about how common this side effect is and whether it's directly caused by the medication itself.
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You would complete surveys about your thinking and memory, take computerized tests to assess concentration and cognitive skills, and provide a saliva sample for research. Your medical records would also be reviewed. If you're in the patient group, you'd do these activities starting before or shortly after you begin the medication and continue at follow-up visits; if you're in the healthy volunteer comparison group, you'd complete the same assessments once to help researchers understand what's normal.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
United States
Sponsor
University of Rochester NCORP Research Base
Collaborators
National Cancer Institute (NCI)
Enrollment target
~400 participants
Started
November 2025
Primary completion
February 2029
Age range
18 Years and older
Last updated on clinicaltrials.gov in June 2026.
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Central contact
Ashley Mack, MS
University of Rochester NCORP Research Base
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