New medication combined with standard therapy for operable lung cancer

Plain-English translation of NCT07642024 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated August 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial is testing whether , a new medication, works better when combined with (a drug already used for lung cancer) compared to other standard treatments. The trial includes people with a specific type of lung cancer that can be surgically removed and have particular genetic mutations. Researchers want to see if this combination helps patients live longer and stay cancer-free.

Current treatments for this type of operable lung cancer don't work for everyone, and some patients get cancer again after surgery. This trial is testing whether the medication combined with existing therapy can improve outcomes and prevent cancer from coming back.

Do you qualify?

You likely qualify if…

you are between 18 and 75 years old
you have been diagnosed with a specific type of lung cancer that can be surgically removed
your tumor has one of the specific EGFR genetic mutations
you are expected to live at least 3 more months
your heart and organ function are healthy enough for treatment
you are willing to use effective contraception if you could become pregnant

You likely don't qualify if…

you have had another type of cancer in the past 5 years
you have had major surgery in the past 4 weeks
you have received chemotherapy or other cancer treatment before
you have serious heart, lung, or blood clotting problems
you have uncontrolled high blood pressure or blood sugar problems

What participation looks like

You would be randomly assigned to receive one of three treatment options, each involving medication given in 3-week cycles. Before starting, you'll have lung function tests and provide a tissue sample from your tumor. Throughout the trial, you'll take the assigned medication(s) and have regular visits to monitor how well the treatment works and check for side effects. Treatment continues for several cycles as long as you're benefiting and tolerating it well.

AI-generated summary from trial data · Aug 8, 2026 · Not medical advice

Trial locations(2 sites)

China

Shanghai East Hospital, Shanghai, Shanghai Municipality

Shanghai Pulmonary Hospital, Shanghai, Shanghai Municipality