Plain-English translation of NCT07643337 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing vagus nerve stimulation (VNS)—a treatment already approved for helping stroke survivors recover arm strength—to see if it can also help improve walking and lower leg function. Participants will have already received VNS as part of standard stroke recovery treatment for their arms. This trial will see if keeping that same device activated during focused leg and walking therapy produces better results than doing the therapy without the device turned on.
Stroke often leaves people with weakness in both their arms and legs, but current treatments work best for arm recovery. Walking and leg strength are critical for people to return to work, spend time with family, and live independently—so researchers want to find better ways to help the legs and gait recover too.
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After completing the standard upper arm recovery program with the vagus nerve stimulator, you will be randomly assigned to one of two groups: one group will do 4.5 months of physical therapy with the device turned on, and the other group will do the same therapy with the device turned off. You'll attend in-clinic therapy sessions and also do exercises at home. Throughout the study, researchers will measure your walking ability and leg strength using clinical tests and laboratory-based movement analysis to see which group improves more.
AI-generated summary from trial data · Jul 4, 2026 · Not medical advice
United States
Sponsor
State University of New York at Buffalo
Enrollment target
~24 participants
Started
June 2026
Primary completion
December 2027
Age range
22 Years – 80 Years
Last updated on clinicaltrials.gov in June 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Ellen M Carl, PhD, CCRP
University at Buffalo
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.