Plain-English translation of NCT07644325 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether doctors can reliably diagnose transthyretin amyloidosis (a rare disease where abnormal proteins build up in the body) by taking a small tissue sample from the wrist ligament during carpal tunnel surgery. Right now, doctors usually take a tissue sample from the lining around the tendons, but that's harder to do with minimally invasive surgery. This study will compare both tissue samples to see if the ligament sample works just as well.
Transthyretin amyloidosis often starts as carpal tunnel syndrome and can cause serious heart problems later if not caught early. New treatments are now available, making early diagnosis crucial—but current testing methods are difficult during minimally invasive surgery. This study aims to find a simpler, safer way to screen for this condition during routine carpal tunnel procedures.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will undergo minimally invasive carpal tunnel surgery at the study center. During the procedure, your surgeon will take two small tissue samples—one from the wrist ligament and one from the tissue lining around the tendons—to test for the rare protein disease. These samples will be analyzed and compared to see if the ligament sample is just as reliable as the standard sample for diagnosis.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
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