Plain-English translation of NCT07646834 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand how your gut bacteria and brain function are connected, especially in people with irritable bowel syndrome (IBS) who also have anxiety or depression. This study will compare people with IBS and these symptoms to healthy volunteers, using advanced brain imaging and stool samples to look for patterns that might help doctors better understand and treat these conditions in the future.
Many people with IBS also struggle with anxiety and depression, but doctors don't fully understand why. This research aims to find out whether changes in gut bacteria are linked to changes in brain function, which could lead to better ways to diagnose and treat these conditions together.
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You will complete questionnaires about your bowel symptoms, mood, sleep, and thinking skills. You'll also provide a small stool sample (about 5 grams) and a blood sample (about 5 milliliters). The main part of the study is a 45–50 minute brain scan using a powerful MRI machine, where you'll lie still inside the scanner. Some IBS patients may be invited back 3 months later to repeat the questionnaires and provide samples again. There are no new medications or treatments involved.
AI-generated summary from trial data · Aug 6, 2026 · Not medical advice
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