Plain-English translation of NCT07652333 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This pilot study is testing whether strength training exercises can help adults who are taking GLP-1 receptor agonist medications (like Ozempic, Wegovy, Zepbound, or Mounjaro) build and preserve muscle mass while losing weight, and whether exercise also improves mental health and quality of life. Half of the participants will do supervised strength training twice a week for 3 months, while the other half will follow standard care with the medication alone during that period.
Weight loss medications are very effective, but some people worry they may lose muscle along with fat. This study is exploring whether adding strength training can help preserve and build muscle during treatment, and whether exercise also boosts mood and overall well-being.
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You would visit the research site for a baseline assessment, then be randomly assigned to either the exercise group or standard care group. If assigned to exercise, you would attend two supervised 60-minute strength training sessions per week for 3 months, using weight machines to perform exercises like chest press, leg press, and rows. Both groups would continue taking their prescribed weight loss medication and wear a pedometer to track daily activity. The study lasts about 3–6 months depending on your group, and researchers will measure your muscle mass, body composition, and mental health at the beginning and end.
AI-generated summary from trial data · Aug 12, 2026 · Not medical advice
United States