Testing a new injection treatment for severe eczema in babies and toddlers

Plain-English translation of NCT07660835 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated August 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This study is testing , a new injectable medication designed to help treat moderate-to-severe eczema in very young children (babies and toddlers from 6 to 23 months old) whose condition hasn't improved with topical creams and ointments. Researchers want to understand how the medication works in this age group, how safe it is, and whether it actually reduces itching and skin inflammation. About 35 babies and toddlers will participate.

Severe eczema in babies and toddlers can be extremely uncomfortable and distressing for both the child and parents. Many young children don't respond well enough to standard topical treatments like creams and steroid ointments alone, so doctors need new options. This medication has shown promise in older children and adults, but it hasn't been studied yet in this very young age group.

Do you qualify?

You likely qualify if…

your child is between 6 and 23 months old at the time of screening
your child has been diagnosed with moderate-to-severe eczema
your child's eczema affects at least 10% of their body surface area
your child's eczema has not improved adequately with topical creams and ointments, or your child has needed systemic medications in the past 6 months
your child's itching severity is rated as at least 4 out of 10 on a itch scale
you are willing and able to follow all study visits and requirements for one year

You likely don't qualify if…

your child weighs less than 5 kilograms (about 11 pounds)
your child has a skin infection within 1 week before the study starts, or has had any infection requiring antibiotics or antivirals within 2 weeks before starting
your child is in the custody or care of a child welfare agency or government authority (rather than with their biological parents or legal guardians)
your child has certain other medical conditions that the research team determines would make participation unsafe

What participation looks like

If your child is enrolled, you'll bring them to clinic visits over about 13 months total. Your child will receive one larger 'loading' dose of the medication as an injection under the skin on Day 1, then smaller doses every 4 weeks for up to 12 months (with the last treatment dose at week 48). You'll also apply a moisturizer daily at home and, if your child was using topical steroid creams before, continue at the same dose. After the treatment period ends, you'll return for follow-up visits for up to 8 more weeks to make sure your child is doing well.

AI-generated summary from trial data · Aug 16, 2026 · Not medical advice

Trial locations(1 site)

United States

Texas Dermatology and Laser Specialist-San Antonio, San Antonio, Texas